Clofibrate-induced myotoxicity in rats. Temporal profile of myopathology.
作者信息
Afifi A K, Hajj G A, Saad S, Tekian A, Bergman R A, Bahuth N B, Abourizk N
出版信息
Eur Neurol. 1984;23(3):182-97. doi: 10.1159/000115701.
PMID:6468459
Abstract
In this report, the temporal sequence of myopathology during a clofibrate-induced muscular syndrome and its recovery in rats is described using histopathologic, histochemical and electron microscopic technics. Two stages of myopathology are described: an early stage characterized by myopathic features, and a later stage characterized by neurogenic features. Although muscle histology returns to normal after 1 week of discontinuing the drug, electron microscopic abnormalities persist through the second week. It is proposed that clofibrate, in addition to its myotoxic effect, may be neurotoxic.
摘要
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