眠尔通中枢作用中的嘌呤能成分。

A purinergic component in the central actions of meprobamate.

作者信息

Phillis J W, Delong R E

出版信息

Eur J Pharmacol. 1984 Jun 1;101(3-4):295-7. doi: 10.1016/0014-2999(84)90174-2.

Abstract

The anxiolytic propanediol carbamate, meprobamate, potentiates the depressant actions of adenosine on the firing of rat cerebral cortical neurons. Meprobamate inhibits the uptake of adenosine by rat cortical synaptosomes at concentrations within the therapeutic range. Potentiation of endogenously released adenosine can account for many of the central actions of meprobamate.

摘要

抗焦虑药丙二醇氨基甲酸酯，即眠尔通，可增强腺苷对大鼠大脑皮层神经元放电的抑制作用。眠尔通在治疗浓度范围内可抑制大鼠皮层突触体对腺苷的摄取。内源性释放的腺苷增强作用可解释眠尔通的许多中枢作用。