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甲基亚硝基脲对植入前怀孕小鼠的致畸作用。

Teratogenic effects of methylnitrosourea on pregnant mice before implantation.

作者信息

Takeuchi I K

出版信息

Experientia. 1984 Aug 15;40(8):879-81. doi: 10.1007/BF01952007.

DOI:10.1007/BF01952007
PMID:6468608
Abstract

Methylnitrosourea at a dose of 10 mg/kg is teratogenic when applied to pregnant mice on gestational days 2.5, 3.5 or 4.5, but has no such effects on gestational days 0.5 and 1.5.

摘要

当在妊娠第2.5、3.5或4.5天给怀孕小鼠施用剂量为10毫克/千克的甲基亚硝基脲时，它具有致畸性，但在妊娠第0.5和1.5天没有这种影响。

相似文献

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Teratogenic effects of methylnitrosourea on pregnant mice before implantation.甲基亚硝基脲对植入前怀孕小鼠的致畸作用。
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引用本文的文献

1
Midgestational abnormalities associated with in vitro preimplantation N-methyl-N-nitrosourea exposure with subsequent transfer to surrogate mothers.与体外植入前N-甲基-N-亚硝基脲暴露相关的中期妊娠异常，随后转移至代孕母体。
Proc Natl Acad Sci U S A. 1985 Dec;82(24):8757-61. doi: 10.1073/pnas.82.24.8757.
2
Inhibition of implantation caused by methylmercury and mercuric chloride in mouse embryos in vivo.甲基汞和氯化汞对小鼠胚胎体内着床的抑制作用。
Bull Environ Contam Toxicol. 1992 Oct;49(4):541-6. doi: 10.1007/BF00196296.

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Effects on mouse blastocysts of in vitro exposure to methylnitrosourea and 3-methylcholanthrene.体外暴露于甲基亚硝基脲和3-甲基胆蒽对小鼠囊胚的影响。
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Congenital effectiveness of an inhibitor of 3 beta-hydroxysteroid dehydrogenase administered before implantation of the rat blastula.
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