Maxson W S, Pittaway D E, Herbert C M, Garner C H, Wentz A C
Fertil Steril. 1984 Sep;42(3):356-9.
The antiestrogenic effect of clomiphene citrate (CC) on cervical mucus was evaluated in women receiving 150 mg CC daily for 5 days. Daily cervical mucus scores and serum estradiol (E2) concentrations were determined in control (n = 25) and CC (n = 24) cycles. E2 concentrations were significantly higher in the CC-treated women (mean +/- standard error of the mean, 1254 +/- 102 pg/ml versus 337 +/- 18 pg/ml, P less than 0.0001). Despite supraphysiologic E2 concentrations, however, cervical mucus scores were significantly reduced in the CC-treated group (P less than 0.01). These data indicate that CC exerts a direct suppressive effect on cervical mucus despite markedly increased E2 concentrations.
在每日接受150毫克枸橼酸氯米芬（CC）治疗5天的女性中，评估了CC对宫颈黏液的抗雌激素作用。在对照周期（n = 25）和CC治疗周期（n = 24）中，测定了每日宫颈黏液评分和血清雌二醇（E2）浓度。接受CC治疗的女性的E2浓度显著更高（均值±均值标准误，分别为1254±102皮克/毫升和337±18皮克/毫升，P<0.0001）。然而，尽管E2浓度高于生理水平，但CC治疗组的宫颈黏液评分显著降低（P<0.01）。这些数据表明，尽管E2浓度显著升高，但CC对宫颈黏液仍有直接抑制作用。
