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小鼠t单倍型的传递比率畸变并非野生型精子退化的结果。

Transmission ratio distortion of mouse t haplotypes is not a consequence of wild-type sperm degeneration.

作者信息

Silver L M, Olds-Clarke P

出版信息

Dev Biol. 1984 Sep;105(1):250-2. doi: 10.1016/0012-1606(84)90282-3.

DOI:10.1016/0012-1606(84)90282-3
PMID:6468763
Abstract

A mouse t-complex-specific DNA probe was used to determine the ratio of t-carrying and (+)-carrying sperm in epididymal, vas deferens, and postejaculatory sperm cell populations from heterozygous (+/t) mice with transmission ratios of greater than 95%. No detectable degeneration of (+)-carrying sperm was observed. In this respect, mouse t haplotypes differ from Drosophila melanogaster SD chromosomes. High transmission of t haplotypes must be a consequence of differential transport and/or differential sperm function during the fertilization process itself.

摘要

使用小鼠t-复合体特异性DNA探针来确定来自杂合子(+/t)小鼠且传递率大于95%的附睾、输精管和射精后精子细胞群体中携带t的精子与携带(+)的精子的比例。未观察到携带(+)的精子有可检测到的退化现象。在这方面,小鼠t单倍型不同于黑腹果蝇的SD染色体。t单倍型的高传递率必定是受精过程中差异运输和/或差异精子功能的结果。

相似文献

1
Transmission ratio distortion of mouse t haplotypes is not a consequence of wild-type sperm degeneration.小鼠t单倍型的传递比率畸变并非野生型精子退化的结果。
Dev Biol. 1984 Sep;105(1):250-2. doi: 10.1016/0012-1606(84)90282-3.
2
A premature acrosome reaction is programmed by mouse t haplotypes during sperm differentiation and could play a role in transmission ratio distortion.在精子分化过程中,小鼠t单倍型会引发过早的顶体反应,这可能在传递比率失真中发挥作用。
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Sperm from mice carrying one or two t haplotypes are deficient in investment and oocyte penetration.携带一个或两个t单倍型的小鼠精子在受精投入和卵母细胞穿透方面存在缺陷。
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Transmission ratio distortion in mouse t-haplotypes is due to multiple distorter genes acting on a responder locus.小鼠t单倍型中的传递比率畸变是由于多个畸变基因作用于一个反应位点所致。
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Elevated galactosyltransferase activity on t-bearing sperm segregates with T/t-complex distorter loci-2.携带t的精子上半乳糖基转移酶活性升高与T/t复合畸变位点-2相关。
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[Transmission ratio disruption, sterility, and control of t-complex function in sperm].[精子中T复合体功能的传递比率破坏、不育与调控]
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Mendelian inheritance of t haplotypes in house mouse ( Mus musculus domesticus) field populations.家鼠(小家鼠)野外种群中t单倍型的孟德尔遗传。
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The t complex-encoded GTPase-activating protein Tagap1 acts as a transmission ratio distorter in mice.t 复合体编码的 GTP 酶激活蛋白 Tagap1 在小鼠中充当传递比率畸变基因。
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Rate of egg penetration in vitro accelerated by T/t locus in the mouse.小鼠中T/t基因座加速体外卵子穿透率。
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Genetic analysis of mammalian spermatogenesis: use of the t complex in the mouse in studies of spermatogenesis and sperm function.哺乳动物精子发生的遗传分析:利用小鼠的t复合体研究精子发生和精子功能。
Ann N Y Acad Sci. 1984;438:206-16. doi: 10.1111/j.1749-6632.1984.tb38287.x.

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Sex-ratio meiotic drive in Drosophila simulans is related to equational nondisjunction of the Y chromosome.拟暗果蝇的性比减数分裂驱动与Y染色体的均等不分离有关。
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Targeted mutagenesis of a candidate t complex responder gene in mouse t haplotypes does not eliminate transmission ratio distortion.对小鼠t单倍型中一个候选t复合体响应基因进行靶向诱变并不能消除传递比失真。
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