Rizzo A, Fiorilli R, Lisanti P
G Ital Cardiol. 1984 May;14(5):377-8.
Few data are currently available regarding the electrophysiological effects of Propafenon administration in patients with pre-existing excito-conduction system disturbances. We have performed electrophysiological evaluation in 18 patients (15 males and 3 females, mean age 61 +/- 9 years - 4 patients with sinus bradycardia, 5 pts with AVN block, 4 patients with bundle branch block and normal HV and 5 patients with bundle branch block and prolonged HV) before and after intravenous administration of Propafenon (1 mg/Kg B.W. in 5 minutes). Propafenone administration decreased the heart rate, significantly lengthened AH and HV intervals, lengthened atrial, ventricular and, above all, AVN refractory periods. In no cases sinus pauses, marked bradycardia, spontaneous A-V block or additional intraventricular conduction disturbances were observed. We conclude that: due to its marked electrophysiological effects on AVN and His-Purkinje system, Propafenon is electively indicated for the treatment of ventricular arrhythmias and paroxysmal supraventricular tachycardia with AVN reentry; Propafenon intravenous administration appears to be safe also in pts with preexisting excitation and conduction disturbances.
目前关于普罗帕酮给药对已有兴奋 - 传导系统紊乱患者的电生理效应的数据很少。我们对18例患者（15例男性和3例女性，平均年龄61±9岁 - 4例窦性心动过缓患者，5例房室结阻滞患者，4例束支阻滞且HV正常患者以及5例束支阻滞且HV延长患者）在静脉注射普罗帕酮（1mg / Kg体重，5分钟内注射完毕）前后进行了电生理评估。给予普罗帕酮后心率降低，AH和HV间期显著延长，心房、心室尤其是房室结不应期延长。未观察到窦性停搏、显著心动过缓、自发性房室传导阻滞或额外的室内传导紊乱情况。我们得出结论：由于普罗帕酮对房室结和希氏 - 浦肯野系统有显著的电生理效应，它被选择性地用于治疗室性心律失常和伴有房室结折返的阵发性室上性心动过速；静脉注射普罗帕酮在已有兴奋和传导紊乱的患者中似乎也是安全的。
