叙利亚金仓鼠中由粗制丁基羟基茴香醚（一种3-叔丁基和2-叔丁基异构体的混合物）诱导的前胃增生是由3-叔丁基羟基茴香醚引起的。
Induction of forestomach hyperplasia by crude butylated hydroxyanisole, a mixture of 3-tert and 2-tert isomers, in Syrian golden hamsters is due to 3-tert-butylated hydroxyanisole.
作者信息
Ito N, Hirose M, Kurata Y, Ikawa E, Mera Y, Fukushima S
出版信息
Gan. 1984 Jun;75(6):471-4.
PMID:6468835
Abstract
Male Syrian golden hamsters were given 1.0% 2-tert- or 3-tert-butylated hydroxyanisole (BHA) or crude BHA for 1 to 4 weeks. The incidence of severe hyperplasia induced in the forestomach was high in the hamsters given 3-tert-BHA or crude BHA for 2 weeks or more, but was almost at the control level in those given 2-tert-BHA. Thus, the 3-tert isomer would appear to be responsible for the tumorigenicity of crude BHA.
摘要
给雄性叙利亚金黄地鼠喂食1.0%的2-叔丁基或3-叔丁基对羟基茴香醚（BHA）或粗制BHA，持续1至4周。在给予3-叔丁基BHA或粗制BHA 2周或更长时间的仓鼠中，前胃诱导的严重增生发生率很高，但在给予2-叔丁基BHA的仓鼠中几乎处于对照水平。因此，3-叔丁基异构体似乎是粗制BHA致瘤性的原因。
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