Morales Castillo M E, Bustamante Calvillo M E, Urrusti Sanz J, Jiménez Gallegos M, Jiménez Balderas E, Navarro Barrón J L, Ruiz-Gómez J
Bol Med Hosp Infant Mex. 1978 Jul-Aug;35(4):673-7.
To determine the concentration of IgM to be used as intrauterine infection indicator, the sera of 2,906 newborns were studied. Five hundred and sixty-three (19.4%), showed high concentrations of IgM and out of 199 pair sera studied, serologic evidence of infection was found in 21.1%. Out of these cases, 80.9% showed no clinical disturbances during their first two months of life. The agents most frequently found responsible for intrauterine infection were cytomegalovirus, influenza A2 H-K, influenza B, parotiditis and rubella. Based on this study, we may conclude that determinations of high concentrations of IgM with the technique used is still a good index to detect intrauterine infections, specially considering that the clinical manifestations of disease may be minimal or may pass unnoticed during the first days of life and that by no means should this test be done instead of other clinical or laboratory studies to investigate such questions.
为确定用作宫内感染指标的IgM浓度，对2906例新生儿的血清进行了研究。563例（19.4%）显示IgM浓度高，在研究的199对血清中，21.1%发现有感染的血清学证据。在这些病例中，80.9%在出生后头两个月无临床症状。最常发现的宫内感染病原体是巨细胞病毒、甲型流感病毒A2 H-K、乙型流感病毒、腮腺炎病毒和风疹病毒。基于这项研究，我们可以得出结论，用所采用的技术测定高浓度IgM仍然是检测宫内感染的一个良好指标，特别是考虑到疾病的临床表现可能很轻微，或者在生命的最初几天可能未被注意到，而且绝不能用这项检测来替代其他临床或实验室研究以调查此类问题。
