Quigley E M, Borody T J, Phillips S F, Wienbeck M, Tucker R L, Haddad A
Gastroenterology. 1984 Oct;87(4):857-66.
Factors controlling the transit of contents between the ileum and cecum should be important determinants of intestinal function; however, the dynamics of the ileocecal region remain largely unexplored in healthy humans. Accordingly, prolonged recordings of intraluminal pressure were obtained from the distal ileum, across the ileocecal sphincter, and from the proximal colon of healthy adults. In one set of studies, 16 subjects each contributed 6 h of basal, fasting recordings; in 2 of the 16, postprandial patterns were also recorded. In a second set, 6 fasting subjects were studied for a total of 120 h. Less than 10% of interdigestive cycles (migrating motor complexes) reached the ileocecal sphincter. The remainder faded out and merged into an active, apparently random pattern of pressure waves that became more intense closer to the sphincter. Discrete, short bursts of phasic pressures migrated rapidly for long distances in the distal ileum and a unique peristaltic wave also migrated rapidly, though infrequently, through the region. Tonic pressures were recorded across the ileocecal sphincter but were present only during the passage of phasic pressure waves; basal tone was minimal. We believe these are the first prolonged observations of motility from the ileocecal sphincter of healthy humans. These descriptions provide insights into and a basis for further studies of a largely unexplored area of the human bowel.
控制回肠和盲肠之间内容物转运的因素应是肠道功能的重要决定因素；然而，在健康人群中，回盲部的动力学仍 largely unexplored 。因此，从健康成年人的回肠末端、穿过回盲括约肌以及近端结肠获取了腔内压力的长时间记录。在一组研究中，16名受试者每人提供了6小时的基础空腹记录；在这16人中，有2人还记录了餐后模式。在第二组研究中，对6名空腹受试者进行了总共120小时的研究。不到10%的消化间期（移行性运动复合波）到达回盲括约肌。其余的逐渐消失，并合并为一种活跃的、明显随机的压力波模式，在靠近括约肌处变得更强烈。离散的、短暂的阶段性压力波在回肠末端迅速远距离迁移，一种独特的蠕动波也迅速迁移，尽管不常见，穿过该区域。在回盲括约肌处记录到张力性压力，但仅在阶段性压力波通过时出现；基础张力最小。我们认为这些是对健康人回盲括约肌运动的首次长时间观察。这些描述为人类肠道一个 largely unexplored 区域的进一步研究提供了见解和基础。
