Poitras P
Gastroenterology. 1984 Oct;87(4):909-13.
In the fasting dog, plasma motilin levels fluctuate with the various phases of the interdigestive migrating complex. In this study, we present data supporting the hormonal status of motilin in the dog, as inducer of the phase III of the interdigestive migrating motor complex. Our argument is based on the following points: (a) synthetic canine motilin (200 ng/kg i.v.) reproducing physiological plasma increases of radioimmunoassayable motilin elicited, in the duodenum, activity fronts migrating aborally and absolutely similar to the phase III of the interdigestive migrating motor complex; (b) immunoneutralization of endogenous motilin by a specific motilin antiserum (7921) eliminated the occurrence of activity fronts in the proximal intestine. Migrating phase IIIs initiated below the ligament of Treitz were still documented, supporting again the existence of a motilin-independent mechanism inducing these fronts, which we have called "ectopic." We therefore believe that motilin can be considered a (inter)digestive hormone in the dog, having the physiological role of controlling the induction of the phase III of the interdigestive migrating complex in the proximal gut.
在禁食的犬类中，血浆胃动素水平会随着消化间期移行性复合运动的不同阶段而波动。在本研究中，我们提供的数据支持胃动素在犬类中的激素状态，即作为消化间期移行性运动复合波第三相的诱导物。我们的观点基于以下几点：(a) 合成的犬胃动素（静脉注射200 ng/kg）可使可通过放射免疫测定的胃动素的血浆水平生理性升高，在十二指肠中引发向口端迁移的活动波锋，且与消化间期移行性运动复合波的第三相完全相似；(b) 用特异性胃动素抗血清（7921）对内源性胃动素进行免疫中和，消除了近端肠道中活动波锋的出现。在Treitz韧带下方启动的移行性第三相仍有记录，这再次支持了存在一种不依赖胃动素的机制来诱导这些波锋，我们将其称为“异位”机制。因此，我们认为胃动素可被视为犬类中的一种（消化）间期激素，具有控制近端肠道消化间期移行性复合运动第三相诱导的生理作用。
