Matzkies F, Köhler M, Webs B
Fortschr Med. 1984 Jun 28;102(24):661-5.
In a double-blind, randomized study, six healthy women were given four different antacids containing aluminium, magnesium or calcium, for a period of seven days, respectively. The antacids investigated were Trigastril 50 Del, Maaloxan Suspension, Kompensan-S forte Suspension and Solugastril 50 Gel. All the antacids tested led to a significant increase in the stool frequency and accelerated stool transit time. The sodium-containing agent produced a significantly greater acceleration as compared with the other antacids. No changes in the sodium, potassium or calcium blood levels were seen prior to and after administration of the various antacids. All preparations reduced phosphate concentrations (significant only with Solugastril an Trigastril). In the case of Maaloxan with a high content of magnesium, the magnesium concentration was increased mildly, but significantly. Irrespective of the dose of aluminium employed, all the antacids resulted in a significant increase in aluminium concentration of between 23 and 36 micrograms/l. All the antacids significantly reduced the excretion of phosphate in the urine. The preparation with a high level of magnesium produced the greatest excretion of magnesium, the preparation containing calcium the greatest excretion of calcium, in 24-hour urine. The results show that the effects on the weight of the stools, the transit time, the consistency of the stools, and on the mineral balance, depends upon the composition of the respective antacid.
在一项双盲随机研究中，六名健康女性分别服用了四种不同的含铝、镁或钙的抗酸剂，为期七天。所研究的抗酸剂有Trigastril 50 Del、Maaloxan混悬液、Kompensan-S forte混悬液和Solugastril 50凝胶。所有测试的抗酸剂均导致大便频率显著增加，并加速了大便通过时间。与其他抗酸剂相比，含钠制剂导致的加速作用显著更大。在服用各种抗酸剂前后，未观察到血钠、血钾或血钙水平的变化。所有制剂均降低了磷酸盐浓度（仅Solugastril和Trigastril显著降低）。对于镁含量高的Maaloxan，镁浓度有轻度但显著的升高。无论使用的铝剂量如何，所有抗酸剂均导致铝浓度显著升高，增幅在23至36微克/升之间。所有抗酸剂均显著降低了尿中磷酸盐的排泄。镁含量高的制剂在24小时尿液中产生的镁排泄量最大，含钙制剂产生的钙排泄量最大。结果表明，抗酸剂对大便重量、通过时间、大便稠度以及矿物质平衡的影响取决于各自抗酸剂的成分。
