依托必利和安慰剂治疗后血浆催乳素水平的变化。
Changed plasma prolactin levels after etoperidone and placebo.
作者信息
Meco G, Casacchia M, Boni B, Cusimano G, Carta A, Iannuccelli M
出版信息
Int J Clin Pharmacol Res. 1984;4(2):117-20.
A neuroendocrinological study was carried out by evaluating plasma prolactin levels after etoperidone i.m. (100 mg) and placebo. Fourteen male inpatients (mean age: 35.36 +/- 11.7 years) with chronic schizophrenia were selected for the study, whose aim was to improve interpretation of the pharmacological activity of etoperidone. The results suggest that etoperidone plays the role of an atypical psychotropic drug since it does not affect prolactin levels. In addition, the drug is devoid of anticholinergic effects, which facilitates its prospective clinical use for medium-term and long-term therapy.
通过评估静脉注射依托哌酮（100毫克）和安慰剂后血浆催乳素水平进行了一项神经内分泌学研究。该研究选取了14名患有慢性精神分裂症的男性住院患者（平均年龄：35.36 +/- 11.7岁），其目的是改善对依托哌酮药理活性的解释。结果表明，依托哌酮起到非典型精神药物的作用，因为它不影响催乳素水平。此外，该药物没有抗胆碱能作用，这有利于其在中期和长期治疗中的临床应用前景。
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