Safety of flurbiprofen in subjects with G-6-PD deficiency. In vivo and in vitro results.
作者信息
Passiu G, Mela Q, Perpignano G, Frigerio R, Cacace E
出版信息
Int J Clin Pharmacol Res. 1984;4(2):137-9.
PMID:6469439
Abstract
The safety of flurbiprofen, a new non-steroidal anti-inflammatory drug was tested in individuals with G-6-PD deficiency. The study was carried out in vitro evaluating the erythrocyte levels of reduced glutathione under basal conditions and after incubation with the drug or acetylphenyl-hydrazine. In the red cells marked with 51Cr, survival was evaluated in vivo before and during flurbiprofen administration. The study shows that flurbiprofen has no oxidating activity in carriers of the G-6-PD Mediterranean variant.
摘要
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