Wilson G, O'Leary D J, Vaughan W
Invest Ophthalmol Vis Sci. 1984 Sep;25(9):1105-8.
When a hypotonic solution is applied to the corneal surface the stroma swells. This well-known osmotic response masks a surprising hydration change in the posterior stroma. This was studied by measuring thickness changes in the anterior, middle, and posterior stroma of the rabbit cornea. Measurements were made continuously for 1 hour following osmotic perturbation of the epithelial surface. The data revealed that following a hypotonic shift on the epithelial surface, the posterior stroma thinned briefly. This unexpected effect is predicted satisfactorily by Klyce and Russell's mathematical model. The method of measuring fluid flow between stromal compartments will allow further development of the model in describing the dynamics of stromal hydration.
当将低渗溶液应用于角膜表面时，基质会肿胀。这种众所周知的渗透反应掩盖了后基质中令人惊讶的水合变化。通过测量兔角膜前、中、后基质的厚度变化来对此进行研究。在对上皮表面进行渗透扰动后连续测量1小时。数据显示，上皮表面发生低渗转变后，后基质会短暂变薄。Klyce和Russell的数学模型能够令人满意地预测这种意外效果。测量基质各层间流体流动的方法将有助于进一步完善该模型以描述基质水合的动态变化。
