Hornstein O P, Stühler C, Schirner E, Simon M
Hautarzt. 1984 Jun;35(6):287-91.
In 177 patients with lichen ruber planus of the oral mucosa and in 177 sex- and age-matched healthy control subjects, the data of 24 laboratory parameters were studied prospectively. Abnormal glucose tolerance was observed in 30.1% of cases and in 11.9% of the control group (P less than or equal to 0.01%). Elevated serum cholesterin levels were found in 35.5% of the lichen ruber patients compared with 17.5% of the control population (P less than or equal to 0.1%). The coexistence of hyperglycemia and hypercholesterolemia was revealed in 11.9% of our lichen ruber patients and in 1.7% of the control group. Similar statistically significant differences in the mentioned parameters were seen in patients with sole skin involvement, as compared to the controls. The possible pathogenetic relationship between lichen ruber and diabetes mellitus is discussed, based on the results of this study.
对177例口腔黏膜扁平苔藓患者以及177例性别和年龄匹配的健康对照者，前瞻性地研究了24项实验室参数的数据。30.1%的病例出现葡萄糖耐量异常，而对照组为11.9%（P≤0.01%）。35.5%的扁平苔藓患者血清胆固醇水平升高，而对照人群为17.5%（P≤0.1%）。11.9%的扁平苔藓患者同时存在高血糖和高胆固醇血症，而对照组为1.7%。与对照组相比，单纯皮肤受累的患者在上述参数上也存在类似的统计学显著差异。基于本研究结果，讨论了扁平苔藓与糖尿病之间可能的发病机制关系。
