Koebelé F, Guidoin R, Fabre J L, Bronn P, Goeau-Brissonnière O, Marois M, Gosselin C, Blais P
J Chir (Paris). 1984 Apr;121(4):283-92.
Saphenous vein homografts preserved by freezing at 40 degrees C in the presence of antibiotics for periods of as much as six months were implanted as part of a clinical evaluation program. Candidates included one requiring femoro-popliteal reconstruction with two separate bypass procedure and reoperations for thrombosis and false aneurysm in the left limb as well as 23 maintenance hemodialysis patients (32 arteriovenous blood access shunts for a total of 424 patient-months). Explanted veins used as femoro-popliteal bypasses were examined after collection incidental to reoperations and autopsy. In-vivo dwell time varied between 7 and 51 months. The femoro-popliteal by-passes exhibited calcification and sclerosis. The dialysis access shunts had average service lives of about a year; 21 were replaced because of thrombosis, 10 were stenosed, 7 had aneurysms and necrosis was present in six. Although this implant provides a workable alternative approach to vascular reconstruction, the rapid degeneration of such veins in vivo is a limitation.
作为临床评估项目的一部分，植入了在40摄氏度下于抗生素存在的情况下冷冻长达六个月保存的大隐静脉同种异体移植物。受试者包括一名需要进行股腘动脉重建并进行两次单独搭桥手术以及因左下肢血栓形成和假性动脉瘤而再次手术的患者，以及23名维持性血液透析患者（32个动静脉血液通路分流，总计424个患者月）。用作股腘动脉搭桥的取出静脉在再次手术和尸检时收集后进行检查。体内留置时间在7至51个月之间。股腘动脉搭桥出现了钙化和硬化。透析通路分流的平均使用寿命约为一年；21个因血栓形成而更换，10个狭窄，7个有动脉瘤，6个出现坏死。尽管这种植入物为血管重建提供了一种可行的替代方法，但这种静脉在体内的快速退化是一个限制因素。
