Bain B J, Wickramasinghe S N, Broom G N, Litwinczuk R A, Sims J
J Clin Pathol. 1984 Aug;37(8):888-94. doi: 10.1136/jcp.37.8.888.
The diagnostic value of the Becton Dickinson Radioassay Kit (125I) for the the assay of red cell folate has been investigated. The assay was acceptable with regards to precision but was non-linear with changing packed cell volume. Sensitivity of the assay was satisfactory, with 24 of 25 folate deficient patients giving red cell folate values which fell below the reference range. Specificity of the assay in the detection of folate deficiency was less satisfactory. As with microbiological assays, a considerable proportion of vitamin B12 deficient patients had low red cell folate values. In addition, low concentrations were found in 12% of patients who were unlikely to be deficient in either vitamin B12 or folic acid.
已对用于红细胞叶酸测定的贝克顿·迪金森放射免疫测定试剂盒（125I）的诊断价值进行了研究。该测定在精密度方面是可接受的，但随着红细胞压积的变化呈非线性。该测定的灵敏度令人满意，25例叶酸缺乏患者中有24例的红细胞叶酸值低于参考范围。该测定在检测叶酸缺乏方面的特异性不太令人满意。与微生物学测定一样，相当一部分维生素B12缺乏患者的红细胞叶酸值较低。此外，在12%不太可能缺乏维生素B12或叶酸的患者中发现了低浓度。
