Cerebral MR and CT imaging in polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy.

Cerebral magnetic resonance (MR) and CT imaging of two patients with polycystic lipomembranous osteodysplasia with sclerosing (PLO-SL) showed widespread progressive central and cortical atrophy. Computed tomography revealed calcifications in the area of the caudate nuclei and putamina in both patients. A reduced volume of brain white matter with deep cortical sulci was the most striking MR finding. Rather short relaxation times in periventricular areas adjacent to ventricular bodies were also observed.