Keyzer J J, Kauffman H F, de Monchy J G, Keyzer-Udding J J, de Vries K
J Allergy Clin Immunol. 1984 Sep;74(3 Pt 1):240-5. doi: 10.1016/0091-6749(84)90252-5.
Urinary N tau-methylhistamine, a unique histamine metabolite, was determined in 29 patients with bronchial asthma before and after inhalation of a control solution on 1 day and before and after allergen inhalation on another day. Twenty-eight patients had an early bronchial-obstructive reaction, defined by a decrease in FEV1 of 20% or more within 1 hr after allergen inhalation. A late bronchial-obstructive reaction, 3 to 8 hr after allergen inhalation, was found in 16 patients. The early bronchial-obstructive reaction was attended with a significantly increased N tau-methylhistamine excretion. The fall in FEV1 was correlated with the degree of bronchial hyperreactivity to histamine, but no significant correlation was found with the increase in urinary N tau-methylhistamine excretion. During the late reaction there was no significant difference in the change in N tau-methylhistamine excretion when the change was compared with that of the control day. These results suggest that a renewed degranulation of lung mast cells during the late bronchial-obstructive reaction is unlikely.
对29例支气管哮喘患者，在一天吸入对照溶液前后以及另一天吸入变应原前后，测定尿中独特的组胺代谢产物N-τ-甲基组胺。28例患者出现早期支气管阻塞反应，定义为吸入变应原后1小时内第1秒用力呼气容积（FEV1）下降20%或更多。16例患者在吸入变应原后3至8小时出现迟发性支气管阻塞反应。早期支气管阻塞反应伴有N-τ-甲基组胺排泄显著增加。FEV1的下降与支气管对组胺的高反应性程度相关，但与尿中N-τ-甲基组胺排泄增加无显著相关性。在迟发性反应期间，将N-τ-甲基组胺排泄变化与对照日变化相比，无显著差异。这些结果表明，在迟发性支气管阻塞反应期间肺肥大细胞再次脱颗粒的可能性不大。
