Bernstein D I, Gallagher J S, Grad M, Bernstein I L
J Allergy Clin Immunol. 1984 Sep;74(3 Pt 1):258-60. doi: 10.1016/0091-6749(84)90255-0.
This is a case report of a patient who developed IgE-mediated sensitization and subsequently ocular angioedema and conjunctivitis from papain contained in a commercial contact lens cleansing solution. Serum-specific IgE and positive cutaneous prick tests to papain and chymopapain were detected. When the lens solution containing papain was stopped, there was resolution of her allergic symptoms. Recognition of this route of papain-induced sensitization may be important in those patients undergoing chemonucleolysis with chymopapain who may be at greater risk to develop a systemic allergic reaction after injection of this enzyme.
这是一例患者的病例报告，该患者因市售隐形眼镜清洁液中含有的木瓜蛋白酶发生了IgE介导的致敏反应，随后出现眼部血管性水肿和结膜炎。检测到针对木瓜蛋白酶和糜木瓜蛋白酶的血清特异性IgE及阳性皮肤点刺试验结果。当停用含木瓜蛋白酶的镜片清洁液后，她的过敏症状得到缓解。认识到这种木瓜蛋白酶诱导的致敏途径对于那些接受糜木瓜蛋白酶化学髓核溶解术的患者可能很重要，因为他们在注射这种酶后发生全身过敏反应的风险可能更高。
