Dienel G A
J Neurochem. 1984 Oct;43(4):913-25. doi: 10.1111/j.1471-4159.1984.tb12825.x.
The regional concentrations of intravenously injected 45Ca and total calcium were measured in rat brain during recovery from transient occlusion of the four major arteries to the brain. 45Ca was injected at intervals after ischemia, and the regional distribution of 45Ca was estimated by autoradiography. The 45Ca appeared to enter the brain via the choroid plexus, labeling the paraventricular tissue at 1 h after the injection. Control brains had more 45Ca in the gray matter compared to fiber-rich areas at 5 and 24 h, but within these regions the optical density was nearly uniform. The accumulation and retention of 45Ca in postischemic brain were selective and time-dependent. The regional pattern of 45Ca uptake correlated with the temporal progression of ischemic cell change. Infarction and preischemic hyperglycemia increased morphological damage, and increased the extent and distribution of 45Ca accumulation. The rise in total calcium concentration appeared to be biphasic in irreversibly damaged tissue.
在大鼠脑从大脑四大主要动脉短暂闭塞恢复过程中，测定了静脉注射的45Ca和总钙在脑内的区域浓度。在缺血后的不同时间间隔注射45Ca，并通过放射自显影估计45Ca的区域分布。45Ca似乎通过脉络丛进入脑内，在注射后1小时标记室旁组织。在5小时和24小时时，对照脑的灰质中45Ca含量比富含纤维的区域多，但在这些区域内光密度几乎均匀。缺血后脑内45Ca的积累和滞留具有选择性且与时间相关。45Ca摄取的区域模式与缺血性细胞变化的时间进程相关。梗死和缺血前高血糖增加了形态学损伤，并增加了45Ca积累的程度和分布。在不可逆损伤的组织中，总钙浓度的升高似乎呈双相性。
