Kemp S F, Creech R H, Horn T R
J Pediatr. 1984 Sep;105(3):394-8. doi: 10.1016/s0022-3476(84)80011-6.
Serum was collected from children with type 1 diabetes mellitus before and 10 days after attending a camp session in which blood glucose concentrations were carefully controlled. Glycosylated and nonglycosylated proteins were separated, and levels of albumin and transferrin were determined on each of these fractions. Glycosylated hemoglobin was also determined and ranged from 4.6% to 14.6% (mean +/- SEM 8.1% +/- 0.2%). Mean initial glycosylated albumin in 73 children was 16.4% +/- 0.6%, which was elevated compared with the mean of levels in 20 nondiabetic controls (8.7% +/- 0.3%) and correlated well with levels of glycosylated hemoglobin (r = 0.71). After 10 days mean glycosylated albumin fell to 14.6% +/- 0.5% (P less than 0.00001), near the predicted final value of 13.4% if control had been ideal. Initial levels of glycosylated transferrin in 44 of these children ranged from 4.5% to 22.3% (11.4 +/- 0.6%) and was significantly higher than the mean of 3.8% +/- 0.3% in 20 nondiabetic controls. Mean final glycosylated transferrin fell to 8.2% +/- 0.3% (P less than 0.00001), near the predicted final mean of 7.0% +/- 0.2%. The mean of each subject's blood glucose determinations performed throughout the study period correlated with final levels of both glycosylated albumin (r = 0.55, P less than 0.001) and glycosylated transferrin (r = 0.54, P less than 0.001). Both glycosylated albumin and glycosylated transferrin appear to be reliable markers of short-term glycemic control; glycosylated transferrin (half-life 8 days) was more sensitive than glycosylated albumin over this 10-day period.
从1型糖尿病患儿中采集血清，分别在参加血糖浓度得到严格控制的野营活动前和活动10天后进行。分离糖化和非糖化蛋白，并测定这些组分中白蛋白和转铁蛋白的水平。同时测定糖化血红蛋白，其范围为4.6%至14.6%（平均值±标准误8.1%±0.2%）。73名儿童的平均初始糖化白蛋白为16.4%±0.6%，与20名非糖尿病对照者的平均水平（8.7%±0.3%）相比有所升高，且与糖化血红蛋白水平相关性良好（r = 0.71）。10天后，平均糖化白蛋白降至14.6%±0.5%（P < 0.00001），若控制理想，接近预测的最终值13.4%。其中44名儿童的初始糖化转铁蛋白水平范围为4.5%至22.3%（11.4±0.6%），显著高于20名非糖尿病对照者的平均水平3.8%±0.3%。平均最终糖化转铁蛋白降至8.2%±0.3%（P < 0.00001），接近预测的最终平均值7.0%±0.2%。在整个研究期间，对每个受试者进行的血糖测定平均值与糖化白蛋白的最终水平（r = 0.55，P < 0.001）和糖化转铁蛋白的最终水平（r = 0.54，P < 0.001）均相关。糖化白蛋白和糖化转铁蛋白似乎都是短期血糖控制的可靠指标；在这10天期间，糖化转铁蛋白（半衰期8天）比糖化白蛋白更敏感。
