酸性晶状体蛋白降解活性：I. 在牛眼组织中的分布
Acidic lens-protein degrading activity: I. Distribution in bovine ocular tissues.
作者信息
Fukuyo T, Hayasaka S, Hara S, Nakazawa M, Mizuno K
出版信息
Jpn J Ophthalmol. 1984;28(2):136-9.
PMID:6471604
Abstract
Bovine lens-protein degradation by ocular tissue homogenates was studied biochemically. Acidic lens-protein degrading activity was widespread in ocular tissues. The ciliary body enzyme, which showed the highest activity at pH 3.8, was inhibited by pepstatin and leupeptin. Lens-protein degrading activity may result from a combination of cathepsins B, D, H and L.
摘要
通过生物化学方法研究了眼组织匀浆对牛晶状体蛋白的降解作用。酸性晶状体蛋白降解活性在眼组织中广泛存在。睫状体酶在pH 3.8时活性最高，被胃蛋白酶抑制剂和亮抑蛋白酶肽抑制。晶状体蛋白降解活性可能是组织蛋白酶B、D、H和L共同作用的结果。
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