Mashiah A, Patel P, Schraibman I G, Charlesworth D
Br J Surg. 1978 May;65(5):342-5. doi: 10.1002/bjs.1800650515.
It has been suggested that, by reducing the viscosity of blood, flow through capillaries is increased with consequent improvement in the symptoms of patients with peripheral vascular disease. We examined the effects of treatment with drugs purported to reduce blood viscosity to test the validity of this claim. Measurements of viscosity and the rate of blood flow to the leg were made in a group of patients before and after treatment with three different drugs--tetranicotinoylfructose (Bradilan), oxypentifylline (Trental) and cinnarizine (Stugeron). All patients had intermittent claudication in one leg and the distribution of arteriosclerosis was similar in each patient. After treatment there was little or no change in blood viscosity and no change in the rate of flow recorded in the symptomatic legs. We did not find any objective evidence to support the use of these drugs in patients with intermittent claudication.
有人认为，通过降低血液粘度，流经毛细血管的血流量会增加，从而改善外周血管疾病患者的症状。我们研究了使用据称能降低血液粘度的药物进行治疗的效果，以检验这一说法的正确性。在一组患者中，在使用三种不同药物（四烟酰果糖（曲克芦丁）、己酮可可碱（培达）和桂利嗪（脑益嗪））治疗前后，测量了粘度和腿部血流量。所有患者均有一条腿间歇性跛行，且每位患者的动脉硬化分布相似。治疗后，血液粘度几乎没有变化，有症状腿部记录的血流量也没有变化。我们没有发现任何客观证据支持在间歇性跛行患者中使用这些药物。
