Stárka L, Obenberger J, Hampl R
Ophthalmic Res. 1984;16(4):190-3. doi: 10.1159/000265315.
Exogenous corticosteroids (dexamethasone, cortisol) inhibit the adrenal secretion of corticosterone in the rabbit and decrease the concentration of corticosterone in aqueous humour, increase glycaemia and cause a rise in glucose concentration in the aqueous. Except for a slight rise 16 h after the corticosteroid administration no effect on plasma or aqueous content of total protein was observed. This is in striking contrast with the increase of proteins in aqueous humour after ACTH injection. Thus it seems likely that corticosteroids do not mediate the effect of ACTH on the disruption of the blood-aqueous barrier.
外源性皮质类固醇(地塞米松、皮质醇)可抑制家兔肾上腺皮质酮的分泌,降低房水中皮质酮的浓度,使血糖升高,并导致房水中葡萄糖浓度上升。除了在给予皮质类固醇16小时后有轻微升高外,未观察到对血浆或房水中总蛋白含量有任何影响。这与注射促肾上腺皮质激素(ACTH)后房水中蛋白质增加形成了鲜明对比。因此,皮质类固醇似乎并未介导ACTH对血-房水屏障破坏的作用。