血浆精氨酸加压素浓度与卡马西平的抗利尿作用
Plasma arginine vasopressin concentrations and antidiuretic action of carbamazepine.
作者信息
Stephens W P, Coe J Y, Baylis P H
出版信息
Br Med J. 1978 Jun 3;1(6125):1445-7. doi: 10.1136/bmj.1.6125.1445.
Abstract
Twelve subjects given therapeutic doses of carbamazepine showed no change in their plasma electrolyte concentrations. Ten of the 12 had abnormal water metabolism, however, their ability to excrete water loads being decreased. Plasma arginine vasopressin (AVP) concentrations fell while the subjects were taking the drug, indicating that the mechanism is unlikely to be increased secretion of antidiuretic hormone. We suggest that the water-retaining property of carbamazepine is a physiological effect of the drug, mediated by increased renal sensitivity to normal plasma concentrations of AVP and resetting of osmoreceptors.
摘要
接受治疗剂量卡马西平的12名受试者血浆电解质浓度未发生变化。然而，这12名受试者中有10名存在水代谢异常，其排出水负荷的能力下降。在受试者服用该药物期间，血浆精氨酸加压素（AVP）浓度下降，这表明其机制不太可能是抗利尿激素分泌增加。我们认为，卡马西平的保水特性是该药物的一种生理效应，由肾脏对正常血浆浓度AVP的敏感性增加和渗透压感受器的重置介导。
相似文献
1
Plasma arginine vasopressin concentrations and antidiuretic action of carbamazepine.血浆精氨酸加压素浓度与卡马西平的抗利尿作用
Br Med J. 1978 Jun 3;1(6125):1445-7. doi: 10.1136/bmj.1.6125.1445.
2
Effect of carbamazepine on plasma and urine arginine-vasopressin.
Clin Sci Mol Med. 1978 Apr;54(4):419-24. doi: 10.1042/cs0540419.
3
Carbamazepine diminishes the sensitivity of the plasma arginine vasopressin response to osmotic stimulation.
J Clin Endocrinol Metab. 1983 Nov;57(5):952-7. doi: 10.1210/jcem-57-5-952.
4
Raised plasma arginine vasopressin concentration in carbamazepine-induced water intoxication.卡马西平所致水中毒时血浆精氨酸加压素浓度升高
Br Med J. 1977 Sep 24;2(6090):804. doi: 10.1136/bmj.2.6090.804.
5
[Changes induced by carbamazepine in the action of ADH (antidiuretic hormone) in neurologic patients].
Riv Neurol. 1988 May-Jun;58(3):106-9.
6
Treatment of diabetes insipidus with carbamazepine.
Lancet. 1975 Nov 15;2(7942):948-51. doi: 10.1016/s0140-6736(75)90361-x.
7
Application of vasopressin radioimmunoassay to clinical study: role of vasopressin in hypo- and hypernatremia and some other disorders of water metabolism.
Contrib Nephrol. 1978;9:42-60. doi: 10.1159/000401432.
8
Effects of oxcarbazepine on sodium concentration and water handling.奥卡西平对钠浓度和水代谢的影响。
Ann Neurol. 2002 May;51(5):613-20. doi: 10.1002/ana.10190.
9
[Serum RIA vasopressin levels in 5 healthy subjects during water loading, before and during treatment by carbamazepine (author's transl)].
Pathol Biol (Paris). 1979 Feb;27(2):95-8.
10
Effects of long-term carbamazepine treatment on water metabolism and plasma vasopressin concentration.长期卡马西平治疗对水代谢及血浆血管加压素浓度的影响。
Eur J Clin Pharmacol. 1984;26(6):719-22. doi: 10.1007/BF00541931.
引用本文的文献
1
Hyponatremia With Anticonvulsant Medications: A Narrative Review.抗惊厥药物所致低钠血症：一篇叙述性综述
Cureus. 2024 Apr 3;16(4):e57535. doi: 10.7759/cureus.57535. eCollection 2024 Apr.
2
Oxcarbazepine Therapy for Complete Central Diabetes Insipidus.奥卡西平治疗完全性中枢性尿崩症
Case Rep Nephrol Dial. 2018 Jan 31;8(1):20-24. doi: 10.1159/000485244. eCollection 2018 Jan-Apr.
3
PRE-OPERATIVE CARBAMAZEPINE-INDUCED HYPONATRAEMIA: SHOULD WE ACCEPT A RESET HYPO-OSMOLAR BASELINE AND PROCEED WITH SURGERY?术前卡马西平所致低钠血症：我们是否应接受低渗基线重置并继续进行手术？
Ulster Med J. 2017 May;86(2):123-124. Epub 2017 May 20.
4
A case of nephrogenic syndrome of inappropriate antidiuresis caused by carbamazepine.一例由卡马西平引起的抗利尿激素分泌失调综合征。
CEN Case Rep. 2018 May;7(1):66-68. doi: 10.1007/s13730-017-0295-9. Epub 2017 Dec 27.
5
Transient Splenial Lesion Following Abrupt Withdrawal of Carbamazepine.卡马西平突然停药后出现的短暂性胼胝体病变
Intern Med. 2017;56(8):989-990. doi: 10.2169/internalmedicine.56.7910. Epub 2017 Apr 15.
6
Reversible splenial lesion syndrome associated with lobar pneumonia: Case report and review of literature.与大叶性肺炎相关的可逆性胼胝体病变综合征：病例报告及文献复习
Medicine (Baltimore). 2016 Sep;95(39):e4798. doi: 10.1097/MD.0000000000004798.
7
Interferon-alpha is a predisposing risk factor for carbamazepine-induced hyponatremia: A case of syndrome of inappropriate antidiuresis caused by interferon-alpha therapy.干扰素-α是卡马西平引起低钠血症的易感危险因素：一例因干扰素-α治疗引起的抗利尿激素不适当分泌综合征。
Int J Gen Med. 2008 Nov 30;1:21-5. doi: 10.2147/ijgm.s2595.
8
The clinical challenge of SIADH-three cases.抗利尿激素分泌失调综合征的临床挑战——三例病例
NDT Plus. 2009 Nov;2(Suppl_3):iii20-iii24. doi: 10.1093/ndtplus/sfp155.
9
Transient focal lesion in the splenium of the corpus callosum: MR imaging with an attempt to clinical-physiopathological explanation and review of the literature.胼胝体压部的短暂局灶性病变：磁共振成像及临床病理生理学解释与文献综述
Radiol Med. 2007 Sep;112(6):921-35. doi: 10.1007/s11547-007-0197-9. Epub 2007 Sep 20.
10
Transient lesion in the splenium of the corpus callosum: three further cases in epileptic patients and a pathophysiological hypothesis.胼胝体压部的短暂性病变：癫痫患者中的另外三例病例及病理生理学假说
J Neurol Neurosurg Psychiatry. 2001 Apr;70(4):459-63. doi: 10.1136/jnnp.70.4.459.
本文引用的文献
1
The antidiuretic action of carbamazepine in man.卡马西平在人体中的抗利尿作用。
Clin Sci Mol Med. 1974 Oct;47(4):289-99. doi: 10.1042/cs0470289.
2
The development of a radioimmunoassay for the measurement of human plasma arginine vasopressin.一种用于测量人血浆精氨酸加压素的放射免疫测定法的开发。
Clin Endocrinol (Oxf). 1977 Aug;7(2):91-102. doi: 10.1111/j.1365-2265.1977.tb01300.x.
Zotero 插件