血浆精氨酸加压素浓度与卡马西平的抗利尿作用
Plasma arginine vasopressin concentrations and antidiuretic action of carbamazepine.
作者信息
Stephens W P, Coe J Y, Baylis P H
出版信息
Br Med J. 1978 Jun 3;1(6125):1445-7. doi: 10.1136/bmj.1.6125.1445.
Abstract
Twelve subjects given therapeutic doses of carbamazepine showed no change in their plasma electrolyte concentrations. Ten of the 12 had abnormal water metabolism, however, their ability to excrete water loads being decreased. Plasma arginine vasopressin (AVP) concentrations fell while the subjects were taking the drug, indicating that the mechanism is unlikely to be increased secretion of antidiuretic hormone. We suggest that the water-retaining property of carbamazepine is a physiological effect of the drug, mediated by increased renal sensitivity to normal plasma concentrations of AVP and resetting of osmoreceptors.
摘要
接受治疗剂量卡马西平的12名受试者血浆电解质浓度未发生变化。然而，这12名受试者中有10名存在水代谢异常，其排出水负荷的能力下降。在受试者服用该药物期间，血浆精氨酸加压素（AVP）浓度下降，这表明其机制不太可能是抗利尿激素分泌增加。我们认为，卡马西平的保水特性是该药物的一种生理效应，由肾脏对正常血浆浓度AVP的敏感性增加和渗透压感受器的重置介导。
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本文引用的文献
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The antidiuretic action of carbamazepine in man.卡马西平在人体中的抗利尿作用。
Clin Sci Mol Med. 1974 Oct;47(4):289-99. doi: 10.1042/cs0470289.
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The development of a radioimmunoassay for the measurement of human plasma arginine vasopressin.一种用于测量人血浆精氨酸加压素的放射免疫测定法的开发。
Clin Endocrinol (Oxf). 1977 Aug;7(2):91-102. doi: 10.1111/j.1365-2265.1977.tb01300.x.
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