维生素B12吸收过程中钴胺素II肠道起源的证据。
Evidence for intestinal origin of transcobalamin II during vitamin B12 absorption.
作者信息
Chanarin I, Muir M, Hughes A, Hoffbrand A V
出版信息
Br Med J. 1978 Jun 3;1(6125):1453-5. doi: 10.1136/bmj.1.6125.1453.
Abstract
The plasma binding of newly absorbed, radioactively labelled vitamin B12 was studied during a urinary excretion (Schilling) test. Vitamin B12, after being absorbed from the gut, enters blood attached to transcobalamin II, which seems to be derived from the ileal enterocyte. The absorbed B12 re-enters the blood stream after the transcobalamin II-B12 complex is cleared by the liver and it is then excreted into the urine during the Schilling test.
摘要
在一项尿液排泄（希林）试验中，对新吸收的放射性标记维生素B12的血浆结合情况进行了研究。维生素B12从肠道吸收后，与钴胺素II结合进入血液，钴胺素II似乎来源于回肠肠细胞。钴胺素II - B12复合物被肝脏清除后，吸收的B12重新进入血流，然后在希林试验期间排泄到尿液中。
相似文献
1
Evidence for intestinal origin of transcobalamin II during vitamin B12 absorption.维生素B12吸收过程中钴胺素II肠道起源的证据。
Br Med J. 1978 Jun 3;1(6125):1453-5. doi: 10.1136/bmj.1.6125.1453.
2
The forms of vitamin B12 on the transcobalamins.钴胺素上维生素B12的形式。
Clin Sci Mol Med. 1977 Feb;52(2):215-8. doi: 10.1042/cs0520215.
3
Formation of transcobalamin II--vitamin B12 complex by guinea-pig ileal mucosa in organ culture after in vivo incubation with intrinsic factor--vitamin B12.在体内与内因子 - 维生素B12孵育后，豚鼠回肠黏膜在器官培养中形成转钴胺素II - 维生素B12复合物。
Br J Haematol. 1978 Nov;40(3):401-14. doi: 10.1111/j.1365-2141.1978.tb05812.x.
4
Human plasma R-type vitamin B12-binding proteins. II. The role of transcobalamin I, transcobalamin III, and the normal granulocyte vitamin B12-binding protein in the plasma transport of vitamin B12.人血浆R型维生素B12结合蛋白。II. 钴胺素I、钴胺素III和正常粒细胞维生素B12结合蛋白在维生素B12血浆转运中的作用。
J Biol Chem. 1975 Oct 10;250(19):7707-13.
5
Binding of vitamin B12--rat transcobalamin II and free vitamin B12 to plasma membranes isolated from rat liver.维生素B12——大鼠转钴胺素II与游离维生素B12与从大鼠肝脏分离的质膜的结合。
Br J Haematol. 1975 Nov;31(3):311-21. doi: 10.1111/j.1365-2141.1975.tb00862.x.
6
Unsaturated and cobalamin saturated transcobalamin I and II in normal human plasma.正常人血浆中不饱和及钴胺素饱和的转钴胺素I和转钴胺素II
Scand J Clin Lab Invest. 1977 Dec;37(8):723-8. doi: 10.3109/00365517709101856.
7
A familial abnormality of circulating vitamin B12 binding proteins: occurrence in a family of high serum concentrations of transcobalamin II.
Br J Haematol. 1976 Jun;33(2):249-59. doi: 10.1111/j.1365-2141.1976.tb03536.x.
8
Transplacental transport in the rabbit of vitamin B12 bound to human transcobalamin I, II and III.维生素B12与人转钴胺素I、II和III结合后在兔体内的胎盘转运。
Br J Haematol. 1979 Dec;43(4):625-30. doi: 10.1111/j.1365-2141.1979.tb03795.x.
9
10
Increased circulating levels of transcobalamin ii in gaucher's disease.
N Engl J Med. 1976 Nov 11;295(20):1096-101. doi: 10.1056/NEJM197611112952002.
引用本文的文献
1
Structural basis of transcobalamin recognition by human CD320 receptor.人 CD320 受体识别钴胺素的结构基础。
Nat Commun. 2016 Jul 14;7:12100. doi: 10.1038/ncomms12100.
2
Cellular uptake of cobalamin: transcobalamin and the TCblR/CD320 receptor.钴胺素的细胞摄取：转钴胺素和 TCblR/CD320 受体。
Biochimie. 2013 May;95(5):1008-18. doi: 10.1016/j.biochi.2013.02.004. Epub 2013 Feb 14.
3
Advances in the understanding of cobalamin assimilation and metabolism.钴胺素吸收和代谢的研究进展。
Br J Haematol. 2010 Jan;148(2):195-204. doi: 10.1111/j.1365-2141.2009.07937.x. Epub 2009 Oct 12.
4
The protein and the gene encoding the receptor for the cellular uptake of transcobalamin-bound cobalamin.参与钴胺素结合转钴胺素细胞摄取的受体的蛋白质及编码该受体的基因。
Blood. 2009 Jan 1;113(1):186-92. doi: 10.1182/blood-2008-05-158949. Epub 2008 Sep 8.
5
Expression of transcobalamin II mRNA in human tissues and cultured fibroblasts from normal and transcobalamin II-deficient patients.转钴胺素II信使核糖核酸在人体组织以及来自正常和转钴胺素II缺乏患者的培养成纤维细胞中的表达。
Biochem J. 1994 Jul 15;301 ( Pt 2)(Pt 2):585-90. doi: 10.1042/bj3010585.
6
Intrinsic factor-mediated absorption of cobalamin by guinea pig ileal cells.内因子介导的豚鼠回肠细胞对钴胺素的吸收。
J Clin Invest. 1983 Mar;71(3):440-8. doi: 10.1172/jci110788.
7
Genetic patterns of transcobalamin II and the relationships with congenital defects.转钴胺素II的遗传模式及其与先天性缺陷的关系。
Mol Cell Biochem. 1983;56(1):5-31. doi: 10.1007/BF00228765.
8
Immunohistochemical localisation of vitamin B12 R-binder in the human digestive tract.维生素B12结合蛋白在人体消化道中的免疫组织化学定位
Gut. 1987 Mar;28(3):339-45. doi: 10.1136/gut.28.3.339.
9
Vitamin B12 absorption and malabsorption.维生素B12的吸收与吸收不良。
Gut. 1989 Dec;30(12):1686-91. doi: 10.1136/gut.30.12.1686.
10
Synthesis and secretion of a cobalamin-binding protein by HT 29 cell line.HT 29细胞系对钴胺素结合蛋白的合成与分泌
Biochem J. 1991 Dec 1;280 ( Pt 2)(Pt 2):427-30. doi: 10.1042/bj2800427.
本文引用的文献
1
Plasma turnover of 57cobalt-vitamin B12 bound to transcobalamin I and II.与钴胺素I和II结合的57钴维生素B12的血浆周转率。
Scand J Haematol. 1967;4(5):321-32. doi: 10.1111/j.1600-0609.1967.tb01633.x.
2
Absorption of vitamin B 12 by the guinea-pig. I. Subcellular localization of vitamin B 12 in the ileal enterocyte during absorption.豚鼠对维生素B₁₂的吸收。I. 吸收过程中维生素B₁₂在回肠肠细胞中的亚细胞定位。
Br J Haematol. 1970 Sep;19(3):369-82. doi: 10.1111/j.1365-2141.1970.tb01634.x.
3
Studies on the transcobalamins.
Br J Haematol. 1973 Dec;25(6):737-49. doi: 10.1111/j.1365-2141.1973.tb01786.x.
4
Measurement of vitamin B12-binding proteins of plasma. I. Technique.
Blood. 1975 Feb;45(2):281-6.
Zotero 插件