Neural crest cells: the role of extracellular matrix in their differentiation and migration.

This paper describes a two-pronged approach to the problem of skull development, tackling on the one hand cyto-differentiation and on the other, pattern formation and morphogenesis through the parameter of migration. Although clearly there are a number of questions still to be answered, it does seem that extracellular matrices are implicated in both aspects of the system. Cell interactions leading to chondrogenic differentiation are apparently matrix-mediated and the presence of type II collagen at the site of the interaction might indicate that it, possibly together with unidentified matrix molecules, has a causal role in such interactions. NC cell locomotion can be arrested by epithelially-derived matrix components causing an aggregation phenomenon. relationship between these two aspects of skull development may be closer than we've indicated. However, initially it will be necessary to define the full range and individual functions of the matrix components present during the events described.