Lee Y T
Prog Clin Biol Res. 1984;156:97-106.
Among 3,528 BCDP-USC screenees, women who had breast cancer before entering the screening program (Group IA) or who had breast cancer detected during the program (Group IB) had a much higher chance of developing a breast cancer later (second primary) than those without any breast cancers (Group II, III, IV). With a median follow-up of seven years after the initial visit (1974-1976), the chances of developing a breast cancer during follow-up study are 24%, 7%, and 0.8% respectively. On the other hand, the chances of developing non-mammary malignancy are not too different between the various cohort groups (2.0-3.3%). Computer analysis of a selected Triad subgroups (487 screenees) also showed that the overall age-specific cancer incidences of our population are similar to that of the 1973-1977 SEER's data. When the relative frequency of specific site of 137 malignancies is concerned, we did see a few more cases of leukemia and melanoma than the SEER's data. However, the number of cases involved is small. Follow-up of all screenees will be continued, and this is only a preliminary report.
在3528名参加乳腺癌检测项目-南加州大学筛查的对象中，在进入筛查项目之前就患有乳腺癌的女性（IA组）或在项目期间检测出患有乳腺癌的女性（IB组），比那些没有患过任何乳腺癌的女性（II组、III组、IV组）日后发生乳腺癌（第二原发性乳腺癌）的几率要高得多。在首次就诊（1974 - 1976年）后进行了为期七年的中位随访，随访研究期间发生乳腺癌的几率分别为24%、7%和0.8%。另一方面，不同队列组发生非乳腺恶性肿瘤的几率差异不大（2.0 - 3.3%）。对选定的三联亚组（487名筛查对象）进行的计算机分析还表明，我们人群中按年龄划分的总体癌症发病率与1973 - 1977年美国癌症监测、流行病学和最终结果计划（SEER）的数据相似。当涉及137种恶性肿瘤的特定部位的相对频率时，我们确实发现白血病和黑色素瘤的病例比SEER的数据略多。然而，所涉及的病例数量很少。所有筛查对象的随访将继续进行，这只是一份初步报告。
