泼尼松龙对家兔安替比林和氯霉素代谢的影响。

Influence of prednisolone on antipyrine and chloramphenicol disposition in rabbits.

作者信息

Shukla V K, Garg S K, Mathur V S

出版信息

Pharmacology. 1984;29(2):117-20. doi: 10.1159/000138000.

Abstract

A study was conducted to see the effect of 15- and 30-day corticosteroid therapy (prednisolone 0.25 mg/kg/day) on the metabolism of antipyrine and chloramphenicol in rabbits. Antipyrine and chloramphenicol were given to rabbits orally at doses of 20 and 50 mg/kg, respectively on days 0, 15 and 30 of prednisolone therapy. The half-life of antipyrine and chloramphenicol were significantly reduced (p less than 0.05) after 15 and 30 days of the corticosteroid therapy. It is concluded that this effect might be due to the induction of liver microsomal enzymes.

摘要

进行了一项研究，以观察15天和30天的皮质类固醇疗法（泼尼松龙0.25毫克/千克/天）对家兔安替比林和氯霉素代谢的影响。在泼尼松龙治疗的第0天、第15天和第30天，分别以20毫克/千克和50毫克/千克的剂量给家兔口服安替比林和氯霉素。皮质类固醇治疗15天和30天后，安替比林和氯霉素的半衰期显著缩短（p小于0.05）。得出的结论是，这种效应可能是由于肝微粒体酶的诱导所致。