[Changes in the composition of phospholipids bound to supramolecular DNA of the thymus and liver in gamma-irradiated rats].

The composition of supramolecular DNA (SM DNA)-bound phospholipids (PL) of thymus and liver of intact rats and those 2 min, 2, 6 and 24 h after gamma-irradiation (9,7 Gy) was studied. In norm, supramolecular DNA of the thymus was shown to contain 6.7 micrograms PL/mg DNA, and that of the liver, 6.1 micrograms PL/mg DNA, the main components of PL being cardiolipin (CL) and phosphatidylethanolamine (PEA). Substantial changes were detected in the PL composition of SM DNA of gamma-irradiated rat organs. During the postirradiation period the concentration of PEA and CL in thymus SM DNA changed symbatically and irreversibly decreased to traces; whereas in SM DNA of the liver, their concentrations changed antibatically and decreased only to a definite level thus maintaining the necessary "lipid volume". It was shown that PL were not restored in SM DNA of the radioresistant liver.