Rodzynek J J, Leautaud P, Damien J, Rosa M P, Govaerts J P
Scand J Haematol. 1984 Aug;33(2):207-11. doi: 10.1111/j.1600-0609.1984.tb02397.x.
In a prospective study, antithrombin III (AT III) was performed preoperatively, peroperatively immediately after the surgical procedure and daily during the 8 postoperative days in 57 consecutive patients who underwent major abdominal surgery without prophylactic anticoagulant therapy. On d 8, according to the results of a bilateral radiological phlebography, the patients were divided into 2 groups: Group I: presence of deep venous thrombosis (DVT): n = 28 (49%) and Group 2: absence of deep venous thrombosis: n = 29 (52%). The results of the study showed that the preoperative AT III value did not constitute a marker of the postoperative DVT risk. During the postoperative period, AT III level decreased immediately following the intervention and resumed its preoperative value within 8 d. Nevertheless, this evolution was not different in the 2 groups and was not related to the presence of postoperative DVT.
在一项前瞻性研究中，对57例连续接受大型腹部手术且未进行预防性抗凝治疗的患者，在术前、手术结束后即刻以及术后8天内每天进行抗凝血酶III（AT III）检测。在第8天，根据双侧放射性静脉造影结果，将患者分为两组：第一组：存在深静脉血栓形成（DVT）：n = 28（49%）；第二组：不存在深静脉血栓形成：n = 29（52%）。研究结果表明，术前AT III值并非术后DVT风险的标志物。术后期间，AT III水平在干预后立即下降，并在8天内恢复到术前值。然而，两组的这种变化并无差异，且与术后DVT的存在无关。
