Martins O O, Dada O A
Toxicol Lett. 1984 Aug;22(2):181-6. doi: 10.1016/0378-4274(84)90064-x.
The effect of the antimalaria drug, chloroquine phosphate, on the transport of [3H]estradiol and [3H]estrone sulphate was studied in isolated sacs of rat duodenum. Net transport of the two estrogens from the mucosal to the serosal sides of the intestinal segment was significantly stimulated at chloroquine concentration of 1.0 mM or higher. However, the transformation of estradiol to estrone glucuronide and of estrone sulphate to estrone, which is normally associated with the transport of these estrogens, was significantly inhibited in the presence of the drug.
在大鼠十二指肠分离囊泡中研究了抗疟药物磷酸氯喹对[3H]雌二醇和[3H]硫酸雌酮转运的影响。当氯喹浓度达到1.0 mM或更高时，肠道段中两种雌激素从黏膜侧向浆膜侧的净转运受到显著刺激。然而，在该药物存在的情况下，通常与这些雌激素转运相关的雌二醇向雌酮葡糖醛酸的转化以及硫酸雌酮向雌酮的转化受到显著抑制。
