Tanii H, Hashimoto K
Toxicol Lett. 1984 Aug;22(2):267-72. doi: 10.1016/0378-4274(84)90077-8.
Acute toxicity, in vitro metabolism and structure-toxicity relationship of aliphatic mononitriles were examined in mice pretreated with carbon tetrachloride (CCl4). The LD50 in mice pretreated with CCl4 (LD50-CCl4) was increased in most nitriles compared to that in untreated animals (LD50-cont.) with different degrees among compounds. Microsomal metabolism of nitriles to CN- was completely inhibited when microsomes were prepared from livers of mice pretreated with CCl4. Log (1/LD50-CCl4) was a linear function of partition coefficient, log P, i.e., log (1/LD50-CCl4) = -0.371 log P-0.152, and the equation was statistically significant (P less than 0.01), provided aceto- and 3-hydroxypropionitrile were omitted from the analysis. These two compounds seem to be different from the others in exerting the biological effect.
在经四氯化碳（CCl4）预处理的小鼠中研究了脂肪族单腈的急性毒性、体外代谢及结构-毒性关系。与未处理动物（LD50-对照）相比，大多数腈类化合物经CCl4预处理的小鼠的半数致死量（LD50-CCl4）有不同程度的增加。当从经CCl4预处理的小鼠肝脏制备微粒体时，腈类化合物向CN-的微粒体代谢被完全抑制。Log(1/LD50-CCl4)是分配系数log P的线性函数，即log(1/LD50-CCl4)= -0.371 log P - 0.152，且该方程具有统计学意义（P<0.01），前提是分析中省略乙酰腈和3-羟基丙腈。这两种化合物在发挥生物学效应方面似乎与其他化合物不同。
