Sauerwein W, Schmitt G, Rehwald U
Strahlentherapie. 1984 Aug;160(8):497-504.
Secondary malignancies are a rare complication after irradiation. 31 observations of such tumours are described, which appeared 4 to 56 years after radiotherapy. The NSD values varied between 400 and 3500 ret. 19 patients developed sarcomas and 12 others carcinomas. The hypotheses of radiation induced tumours and their clinical relevance are discussed. Three patient groups at risk may be distinguished: 1. children, 2. patients who received several treatment series, 3. patients who received combined radio- and chemotherapy.
继发性恶性肿瘤是放疗后一种罕见的并发症。本文描述了31例此类肿瘤的观察结果，这些肿瘤在放疗后4至56年出现。NSD值在400至3500ret之间变化。19例患者发生肉瘤，另外12例发生癌。讨论了辐射诱发肿瘤的假说及其临床相关性。可区分出三组高危患者：1.儿童；2.接受多个疗程治疗的患者；3.接受放疗和化疗联合治疗的患者。
