泼尼松龙治疗对早产新生羔羊选定呼吸参数及心输出量的影响。
Effect of prednisolone treatment on selected respiratory parameters and cardiac output in prematurely delivered neonatal lambs.
作者信息
Thompson F N, van Kampen M, Culver D H
出版信息
Can J Comp Med. 1978 Jan;42(1):132-8.
Lambs were delivered by hysterotomy on days 142 and 143 postcoitum and were assigned to either a control group or a prednisolone-treated group (10 mg/kg daily for four days). On days 1 through 3 of life erythrocyte 2,3-diphosphoglycerate values were significantly increased in the treated group. Prednisolone treatment did not result in significantly increased P50 values. Mean plasma corticoid values in the control group decreased gradually postpartum. The prednisolone-treated lambs compared to the control lambs had depressed corticoid values, differing significantly on day 4. Body weight gains were significantly depressed by treatment and this effect lasted beyond the treatment period. On day 1 of life (24 hours postinitial treatment) oxygen consumption and cardiac output were significantly elevated in the treated group.
在妊娠后142天和143天通过剖宫产分娩羔羊，并将其分为对照组或泼尼松龙治疗组（每天10mg/kg，共四天）。在出生后的第1至3天，治疗组的红细胞2,3-二磷酸甘油酸值显著升高。泼尼松龙治疗并未导致P50值显著升高。对照组的平均血浆皮质激素值在产后逐渐下降。与对照羔羊相比，泼尼松龙治疗的羔羊皮质激素值降低，在第4天有显著差异。治疗显著抑制了体重增加，且这种影响在治疗期后仍持续存在。在出生第1天（初始治疗后24小时），治疗组的耗氧量和心输出量显著升高。
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