Edjtehadi M, Szabuniewicz M, Emmanuel B
Can J Comp Med. 1978 Jan;42(1):63-8.
Twenty-seven sheep were assigned to three groups in order to study acute urea toxicity. Groups I, II and III were dosed with 0.5, 0.6 annd 0.75 g/kg of urea, respectively. The mean survival times were 165, 109 and 60 minutes, respectively. The following clinical signs such as pronounced muscle fasciculation, trembling, grinding teeth, ataxia, lateral recumbency, bloating, regurgitation, hyperesthesia, mydriasis and convulsions were observed. Anuria and lack of salivation were also present. The primary cause of death in this study was due to respiratory arrest and not cardiovascular collapse. Plasma examinations showed a marked increase in glucose, ammonia and urea levels but no change in ketone body concentration.
为研究急性尿素中毒，将27只绵羊分为三组。第一组、第二组和第三组分别给予0.5、0.6和0.75克/千克的尿素。平均存活时间分别为165分钟、109分钟和60分钟。观察到以下临床症状，如明显的肌肉震颤、颤抖、磨牙、共济失调、侧卧、腹胀、反流、感觉过敏、瞳孔散大和抽搐。也出现了无尿和流涎减少的情况。本研究中死亡的主要原因是呼吸骤停而非心血管衰竭。血浆检查显示葡萄糖、氨和尿素水平显著升高，但酮体浓度无变化。
