Adaptive processes controlling sensitivity of short-wave cone pathways to different spatial frequencies.

The sensitivity of the short-wave cone pathways was measured with violet interference gratings on monochromatic adapting fields. Spectral field sensitivity functions for test gratings of 2, 4 and 8 c/deg approximately matched Stiles' pi 3 function, which presumably reflects light-adaptation of the short-wave cones. Previous work had suggested that field sensitivity varies as a function of test spatial frequency, but this now seems an artifact of spatial adaptation. (The present study shows the pathway is highly susceptible to spatial adaptation induced by fine patterns.) For various spatial frequencies that affect the short-wave pathway, signals also pass through a cancellate adaptation site where signals from the short-wave and the middle- and long-wave cones act in opposition. Transient inputs in either opponent direction polarize or desensitize the opponent site. Additional transient inputs of the opposite sign then reduce the polarization and increase sensitivity. Such effects were demonstrated with test gratings as high as 12 c/deg. Transient effects at the opponent site are particularly evident at higher spatial frequencies.