Bolton G C, Allen G D, Filer C W, Jeffery D J
Xenobiotica. 1984 Jun;14(6):483-90. doi: 10.3109/00498258409151435.
At least one third of an oral dose of sodium [G-14C]clavulanate was absorbed by rat and dog. Excretion of radioactivity was rapid in both species. In addition to urinary and faecal excretion of radioactivity, appreciable elimination of 14CO2 occurred, particularly in the rat. This was produced in part by the action of the gut microflora. In the rat, only a small proportion of the radioactive dose was secreted in the bile. The major metabolite in urine was identified as 1-amino-4-hydroxybutan-2-one. Clavulanic acid was also a major component in urine.
大鼠和犬口服[G-14C]克拉维酸钠剂量的至少三分之一可被吸收。两种动物放射性物质的排泄均很快。除了放射性物质经尿液和粪便排泄外，还出现了可观的14CO2消除，尤其是在大鼠中。这部分是由肠道微生物群的作用产生的。在大鼠中，只有一小部分放射性剂量经胆汁分泌。尿液中的主要代谢物被鉴定为1-氨基-4-羟基丁-2-酮。克拉维酸也是尿液中的主要成分。
