Zsolnai B, Lintner F, Somogyi J, Balogh I
Acta Chir Hung. 1984;25(3):169-77.
Subcellar localization of ionic Ca was investigated by the Pb-acetate cytochemical method in rat myometrium on the 21st day of pregnancy, following oxytocin and Bricanyl treatment. Following Oxytocin treatment the amount of ionic Ca increased in the muscle cells of the uterus and decreased in the plasma membrane and mitochondria as compared with the control. Tocolytics given in the last four days of pregnancy caused a decrease in the cytoplasmic concentration of ionic Ca and increased the Ca++ content of Ca++ pools (plasma membrane, mitochondrium). The change in the intracellular distribution of Ca++ may be involved in the mechanism of action of tocolytics and in the development of the relaxation of smooth muscle.
采用醋酸铅细胞化学方法，对妊娠第21天经催产素和间羟舒喘宁处理的大鼠子宫肌层中离子钙的亚细胞定位进行了研究。与对照组相比，催产素处理后子宫肌细胞中离子钙的含量增加，而质膜和线粒体中的离子钙含量减少。在妊娠最后四天给予宫缩抑制剂可导致离子钙的细胞质浓度降低，并增加钙池（质膜、线粒体）中的钙离子含量。钙离子在细胞内分布的变化可能参与了宫缩抑制剂的作用机制和平滑肌舒张的发生过程。
