The oral glucose tolerance test: an objective method of interpretation.

Oral glucose tolerance test results from a positively-skewed, unimodal distribution were analyzed in such a way as to uncover a natural division within the set of results for each time point. The division in results was obtained from a break in the curve formed when plasma glucose concentration was plotted vs the percentile of the population described by those concentrations. The percentile at which the break occurs separated normal from abnormal glucose concentrations objectively. Previously natural divisions between normal and abnormal glucose concentrations had been found only in bimodal distributions from atypical populations such as the Pima Indians and Nauruans of Micronesia. The glucose concentrations at which separations in our unimodal distribution occur compare well with the available data from the atypical populations. According to one measure of reliability, the 3-h time point was more effective than the more commonly utilized 2-h point in distinguishing normal from abnormal plasma glucose concentration.