Lewis J M, Klein-Schwartz W, Benson B E, Oderda G M, Takai S
Am J Dis Child. 1984 Oct;138(10):944-6. doi: 10.1001/archpedi.1984.02140480046014.
A 31-month-old girl required constant intravenous (IV) infusion of naloxone hydrochloride to treat codeine-induced respiratory and CNS depression. The infusion rate was 0.4 mg/hr (27 micrograms/kg/hr) over nine hours, without apparent side effects or evidence of toxic effects, for a total naloxone hydrochloride dose of 4.1 mg (280 micrograms/kg). Constant naloxone hydrochloride infusion at an initial rate of 0.4 mg/hr in pediatric narcotic poisoning should be considered if the patient responds inadequately to an initial 0.01-mg/kg bolus, requires repeated administration to reverse narcotic-induced effects, or has ingested long-acting agents. Continuous IV naloxone infusion is a convenient, safe, and effective method to treat narcotic overdose.
一名31个月大的女孩需要持续静脉输注盐酸纳洛酮来治疗可待因引起的呼吸和中枢神经系统抑制。在9小时内输注速率为0.4毫克/小时（27微克/千克/小时），没有明显的副作用或中毒效应证据，盐酸纳洛酮总剂量为4.1毫克（280微克/千克）。如果患者对初始0.01毫克/千克的静脉推注反应不足、需要反复给药以逆转麻醉诱导的效应或摄入了长效药物，则应考虑在小儿麻醉中毒时以0.4毫克/小时的初始速率持续输注盐酸纳洛酮。持续静脉输注纳洛酮是治疗麻醉过量的一种方便、安全且有效的方法。
