Carroll R R, Panush R S, Kitchens C S
Am J Hematol. 1984 Oct;17(3):321-5. doi: 10.1002/ajh.2830170312.
The few inhibitors to blood coagulation factor IX in patients with Christmas disease (hemophilia B) that have been studied have been shown to belong to the IgG class of immunoglobulins. We report the first case in which a factor IX inhibitor was of the IgA class. Additionally, he appears to be the youngest patient with hemophilia B to have developed an inhibitor. His inhibitor complicated treatment of the patient for several years because of its anamnestic rise following factor IX concentrate administration. It then spontaneously vanished and has not returned in spite of repeated factor IX complex administration.
在已研究的患有克里斯马斯病（血友病B）的患者中，少数凝血因子IX抑制剂已被证明属于免疫球蛋白IgG类。我们报告了首例凝血因子IX抑制剂为IgA类的病例。此外，他似乎是患血友病B并产生抑制剂的最年轻患者。由于其在给予凝血因子IX浓缩物后呈记忆性升高，该抑制剂使患者的治疗复杂化了数年。随后它自行消失，尽管反复给予凝血因子IX复合物，它也未再出现。
