Wood C E, Keil L C, Rudolph A M
Am J Physiol. 1984 Sep;247(3 Pt 2):R589-94. doi: 10.1152/ajpregu.1984.247.3.R589.
The purpose of this study was to test the role of carotid arterial mechanoreceptors in the control of vasopressin secretion in conscious 6- to 7-wk-old lambs. Bilateral carotid occlusion decreased lingual arterial pressure and stimulated reflex increases in heart rate and femoral arterial blood pressure but did not significantly alter plasma concentrations of vasopressin. Acute vagosympathetic blockade, produced by injection of 2% lidocaine onto the vagosympathetic trunks, did not significantly alter heart rate or blood pressure but did stimulate a slow increase in plasma vasopressin concentration, suggesting that afferent vagal fibers tonically inhibit vasopressin secretion. Bilateral carotid occlusion after vagosympathetic blockade stimulated a brisk increase in plasma vasopressin that was larger than the response to vagosympathetic blockade alone. These results suggest that vasopressin secretion in lambs is partially controlled by arterial mechanoreceptors in the carotid sinus and by extracarotid receptors with vagosympathetic afferent fibers.
本研究的目的是测试颈动脉机械感受器在6至7周龄清醒羔羊血管加压素分泌控制中的作用。双侧颈动脉闭塞降低了舌动脉压，并刺激心率和股动脉血压反射性升高，但并未显著改变血管加压素的血浆浓度。通过向迷走交感干注射2%利多卡因产生的急性迷走交感神经阻滞，并未显著改变心率或血压，但确实刺激了血浆血管加压素浓度的缓慢升高，这表明迷走神经传入纤维对血管加压素分泌具有紧张性抑制作用。迷走交感神经阻滞后的双侧颈动脉闭塞刺激血浆血管加压素迅速升高，且升高幅度大于单独迷走交感神经阻滞的反应。这些结果表明，羔羊血管加压素的分泌部分受颈动脉窦中的动脉机械感受器以及具有迷走交感神经传入纤维的颈动脉外感受器控制。
