接受化学免疫疗法的患者肝脏药物去甲基化减少。

Decreased hepatic drug demethylation in patients receiving chemo-immunotherapy.

作者信息

Lipton A, Hepner G W, White D S, Harvey H A

出版信息

Cancer. 1978 May;41(5):1680-4. doi: 10.1002/1097-0142(197805)41:5<1680::aid-cncr2820410506>3.0.co;2-r.

DOI:10.1002/1097-0142(197805)41:5<1680::aid-cncr2820410506>3.0.co;2-r

Abstract

The effect of immunotherapy and chemotherapy on hepatic N-demethylation of aminopyrine was studied by means of the aminopyrine breath test (ABT) in 32 patients with cancer. The aminopyrine breath test (ABT) was decreased in 3 of 11 patients (27.3%) receiving intradermal BCG (+/- DTIC) at a dose of 3 X 10(7) viable organisms. One of 4 (25%) patients receiving intradermal BCG (+/- DTIC) at 3 X 10(8) viable organisms per dose developed an altered ABT. Changes were not seen in patients receiving aerosol BCG (2 patients), and intravenous C. parvum (2 patients), subcutaneous C. parvum (3 patients), and intravenous Cyclophosphamide (2 patients). Six of 7 patients (85.7%) receiving both intravenous C. parvum and Cyclophosphamide had a decreased ABT. These data indicate that chemo-immunotherapy depressed hepatic aminopyrine N-demethylation and suggests that patients treated with chemoimmunotherapy should be carefully observed for possible alterations of hepatic drug metabolism.

摘要

通过氨基比林呼吸试验（ABT）研究了免疫疗法和化学疗法对32例癌症患者肝脏中氨基比林N-去甲基化的影响。11例接受皮内注射剂量为3×10⁷活生物体的卡介苗（±达卡巴嗪）的患者中有3例（27.3%）氨基比林呼吸试验（ABT）降低。4例接受每剂3×10⁸活生物体皮内注射卡介苗（±达卡巴嗪）的患者中有1例ABT发生改变。接受雾化卡介苗（2例患者）、静脉注射小隐孢子虫（2例患者）、皮下注射小隐孢子虫（3例患者）和静脉注射环磷酰胺（2例患者）的患者未出现变化。7例同时接受静脉注射小隐孢子虫和环磷酰胺的患者中有6例（85.7%）ABT降低。这些数据表明化学免疫疗法会抑制肝脏氨基比林N-去甲基化，并提示接受化学免疫疗法治疗的患者应密切观察是否有肝脏药物代谢的可能改变。