Alroy J, Teramura K, Miller A W, Pauli B U, Gottesman J E, Flanagan M, Davisohn I, Weinstein R S
Cancer. 1978 May;41(5):1739-45. doi: 10.1002/1097-0142(197805)41:5<1739::aid-cncr2820410514>3.0.co;2-7.
ABH tissue isoantigens were measured by the Specific Red Cell Adherence (SRCA) test in 66 surgical specimens of urinary bladder, including 53 transitional cell carcinomas, 2 squamous cell carcinomas and 11 controls. The SRCA test was strongly positive in 10 of 11 controls. ABH isoantigens were absent or equivocally present in 68 percent of noninvasive carcinomas (stage 0) and in 65 percent of invasive carcinomas. Clinical histories revealed that all patients with invasive carcinoma who had strongly positive SRCA test results had received prior radiotherapy to the bladder region. None of the patients with invasive bladder carcinoma with negative or weakly positive SRCA tests had been radiated. Histopathology of tumors in both groups was similar. Results of this retrospective study support the hypothesis that radiation may induce differentiation in tumors, possibly through an enhancement of Golgi apparatus function. The SRCA test should not be used as a predictor of the biological behavior of future recurrences in patients with bladder carcinoma who have received therapeutic radiation since radiation may produce "false positive" SRCA test results.
采用特异性红细胞黏附（SRCA）试验检测了66例膀胱手术标本中的ABH组织同种抗原，其中包括53例移行细胞癌、2例鳞状细胞癌和11例对照。11例对照中有10例SRCA试验呈强阳性。68%的非浸润性癌（0期）和65%的浸润性癌中ABH同种抗原缺失或呈弱阳性。临床病史显示，所有SRCA试验结果呈强阳性的浸润性癌患者之前均接受过膀胱区域的放疗。SRCA试验呈阴性或弱阳性的浸润性膀胱癌患者均未接受过放疗。两组肿瘤的组织病理学相似。这项回顾性研究的结果支持以下假设：放疗可能通过增强高尔基体功能诱导肿瘤分化。对于接受过治疗性放疗的膀胱癌患者，SRCA试验不应作为未来复发生物学行为的预测指标，因为放疗可能产生“假阳性”SRCA试验结果。
