Hirobe T
Anat Rec. 1984 Aug;209(4):425-32. doi: 10.1002/ar.1092090402.
In the dorsal epidermis of both C57BL/10J (black, BB) and C57BR/cdJ (brown, bb) mice, the number of melanocytes positive to the dopa reaction (melanocyte population) increases from birth to day 3 or 4, and then gradually decreases. However, the number of melanoblasts plus melanocytes positive to the combined dopa-premelanin reaction (melanoblast-melanocyte population) remains constant until day 3 or 4 and then decreases in the two strains. Despite the similarity of the developmental dynamics in both black and brown mice, there is a significant difference in the number of differentiated melanocytes. Melanocytes are more numerous and more dopa-reactive in brown mice than in black. The maximal density of the melanoblast-melanocyte population on day 3 or 4 does not differ in brown and black mice. Moreover, the maximal density of the melanocyte population in brown epidermis does not differ from that of the melanoblast-melanocyte population of both brown and black. These results indicate that b allele, when homozygous, enhances the differentiation of epidermal melanoblasts by inducing high tyrosinase activity.
在C57BL/10J（黑色，BB）和C57BR/cdJ（棕色，bb）小鼠的背部表皮中，多巴反应阳性的黑素细胞数量（黑素细胞群体）从出生到第3或4天增加，然后逐渐减少。然而，多巴-前黑素联合反应阳性的成黑素细胞加黑素细胞数量（成黑素细胞-黑素细胞群体）在第3或4天之前保持恒定，然后在这两个品系中减少。尽管黑色和棕色小鼠的发育动态相似，但分化的黑素细胞数量存在显著差异。棕色小鼠中的黑素细胞比黑色小鼠中的更多且多巴反应性更强。棕色和黑色小鼠在第3或4天的成黑素细胞-黑素细胞群体的最大密度没有差异。此外，棕色表皮中黑素细胞群体的最大密度与棕色和黑色小鼠的成黑素细胞-黑素细胞群体的最大密度没有差异。这些结果表明，b等位基因纯合时，通过诱导高酪氨酸酶活性增强表皮成黑素细胞的分化。
