关于空气污染对人体致癌负荷的调查。叙利亚仓鼠气管内滴注苯并(a)芘与牛血清白蛋白的研究。
Investigations on the carcinogenic burden by air pollution in man. Intratracheal instillation studies with benzo(a)pyrene in bovine serum albumin in Syrian hamsters.
作者信息
Ketkar M, Reznik G, Schneider P, Mohr U
出版信息
Cancer Lett. 1978 Apr;4(4):235-9. doi: 10.1016/s0304-3835(78)94787-0.
The chronic effect of benzo(a)pyrene (B(a)P) administered intratracheally in bovine serum albumin was studied in Syrian golden hamsters. Dose levels of 0.1 mg, 0.33 mg and 1.0 mg of B(a)P induced papillomas and carcinomas of the trachea, stem bronchi and bronchioles. In addition to such tumours, the mucosa of the respiratory tract revealed a variety of atypical epithelial alterations. Although survival time exhibited a dose-dependency, tumour incidence did not. The incidence of respiratory tract tumours was higher in female hamsters than in males. The results of these investigations are statistically evaluated.
在叙利亚金仓鼠中研究了气管内给予苯并(a)芘（B(a)P）与牛血清白蛋白混合物的慢性影响。0.1毫克、0.33毫克和1.0毫克剂量水平的B(a)P诱发了气管、主支气管和细支气管的乳头状瘤和癌。除了这类肿瘤外，呼吸道黏膜还出现了多种非典型上皮改变。虽然生存时间呈现剂量依赖性，但肿瘤发生率并非如此。雌性仓鼠呼吸道肿瘤的发生率高于雄性。对这些研究结果进行了统计学评估。
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