Mackinnon S E, Dellon A L, Hudson A R, Hunter D A
Ann Plast Surg. 1984 Aug;13(2):112-20. doi: 10.1097/00000637-198408000-00004.
This study reports a rat model of chronic nerve compression. The sciatic nerves of adult male Sprague Dawley rats were bonded with 1-cm lengths of tubing with varying internal diameters. Histological and electrical studies as well as studies to assess the blood-nerve barrier function were carried out at one through six months. With marked compression of the sciatic nerve, profound electrical changes were noted as early as one month, and histological findings were those of degeneration and regeneration. In the rats with minimal compression, nerve conduction studies remained normal. The earliest findings were alterations in the blood-nerve barrier, followed by histological changes in the large myelinated fibers at the periphery of the fascicles and changes about the nodes of Ranvier. This model appears to be a valid one with which to study other aspects of both the pathophysiology and treatment of chronic nerve compression.
本研究报告了一种慢性神经压迫大鼠模型。成年雄性斯普拉格-道利大鼠的坐骨神经用内径不同的1厘米长的管子进行捆绑。在1至6个月时进行了组织学和电学研究以及评估血神经屏障功能的研究。随着坐骨神经受到明显压迫，早在1个月时就注意到了深刻的电学变化，组织学结果显示为变性和再生。在轻度压迫的大鼠中，神经传导研究仍正常。最早的发现是血神经屏障的改变，随后是束外周大的有髓纤维的组织学变化以及郎飞结周围的变化。该模型似乎是一个有效的模型，可用于研究慢性神经压迫的病理生理学和治疗的其他方面。
