Tawa A, Hara J, Yumura K, Doi S, Tomita K, Ikeda T, Sakurai M
Gan To Kagaku Ryoho. 1984 Aug;11(8):1687-91.
A case with large primary mediastinal seminoma responded very well to chemotherapy. A 13-year-old boy was evaluated for complaints of edematous face and neck. Chest radiography and computerized tomography revealed a large anterior superior mediastinal mass. Needle biopsy demonstrated seminoma. After two-drug combination chemotherapy with vincristine and prednisolone and three-drug combination with vincristine, prednisolone and cyclophosphamide, there was a considerable regression of the mediastinal mass. The lower neck and mediastinum were irradiated at a dose of 3,750 rad after cessation of chemotherapy. The patient has been asymptomatic without evidence of recurrence for a follow-up period of more than four years.
一例原发性大纵隔精原细胞瘤患者对化疗反应良好。一名13岁男孩因面部和颈部水肿前来就诊。胸部X线和计算机断层扫描显示前上纵隔有一个大肿块。针吸活检证实为精原细胞瘤。先后采用长春新碱和泼尼松龙两药联合化疗以及长春新碱、泼尼松龙和环磷酰胺三药联合化疗后，纵隔肿块明显缩小。化疗结束后，对下颈部和纵隔进行了3750拉德的放射治疗。在超过四年的随访期内，患者无症状，无复发迹象。
